GDC-0152
CAY-17810-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
873652-48-3
Formulation
A crystalline solid
Purity
≥95%
MW
498,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Inhibitor of apoptosis proteins (IAPs), which block various signaling pathways leading to apoptotic cell death, are commonly over-expressed in cancer cells.{9448} GDC-0152 is a potent inhibitor of specific IAPs that binds baculoviral IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2 (c-IAP1) BIR3, and BIRC3 (c-IAP2) BIR3, respectively).{29254} GDC-0152 induces activation of caspases, decreasing the viability of cancer cells without affecting normal cells.{29254,29255} It is orally bioavailable and suppresses tumor growth in breast cancer xenografts in mice.{29254} GDC-0152 also induces NF-κB transcriptional activity, resulting in the expression of several cytokines, including TNF-α.{29253} In dogs and rats, but not humans, this leads to a pronounced inflammatory response.{29253}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
