Fevipiprant
CAY-20263-1 1 mg
Data Sheet: 
SDS:
SDS:
CAS
872365-14-5
Formulation
A crystalline solid
Purity
≥98%
MW
426,4
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Fevipiprant is a DP2/CRTH2 antagonist (Ki = 1.05 nM).{32112} It reduces shape change of eosinophils induced by prostaglandin D2 (PGD2; Item No. 12010) with IC50 values of 0.4 and 0.44 nM for isolated human eosinophils and human whole blood, respectively. Fevipiprant inhibits PGD2-induced release of IL-5 and IL-13 in isolated human CD4+ Th2 cells (IC50s = 2.56 and 1.4 nM, respectively). It reduces the number of eosinophils in bronchoalveolar lavage fluid (BALF) in a mouse model of asthma (ED50 = ~1 mg/kg).{57949}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
