Emetine (hydrochloride hydrate)

  CAY-21048-100 100 mg

Data Sheet:     SDS:    

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7083-71-8  

A crystalline solid  

≥85%  

553,6  

-20  

-20  

730  

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Description

 

Emetine is an alkaloid that has been found in ipecac root and has diverse biological activities.{53660,31081,36705,53655} It is active against several strains of E. histolytica amoebae (IC50s = 0.73-10.22 μg/ml).{53660} Emetine inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay), increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM), and is cytotoxic to HeLa cells.{31081} It reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50s = 0.46 and 0.5 μM, respectively).{53655} Emetine (5 mg/kg) induces emesis in ferrets, an effect that can be prevented by the serotonin (5-HT) receptor subtype 5-HT3 antagonist ondansetron.{36705}

 

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