EZH2 (Y641S) /EED/SUZ12/RbAp48/AEBP2, His-tag, FLAG-tag Recombinant
BPS-51013 20 µg
Synonyms: KTM6A, EZH2, PRC2, Enhancer Of Zeste Homolog 2, EZH2 (Y646S), EZH, Retinoblastoma Binding Protein 4 (RBBP4)
Data Sheet: 
Reactivity
Human
Applications
Useful for Western blot analysis and to investigate protein-protein interactions in the EZH2 complex.
Source / Host
insect
MW
325 kDa (complex)
Shipment
-80°C (dry ice)
Literature References
1. Varambally, S. et al. Science 322 (5908), 1695-1699 (2008).
2. Rakotobe, D. et al., Virol. J. 5, 32 (2008). Application Reference: Morin, R.D., et al. Nat Genet. 2010 February; 42(2): 181-185.
2. Rakotobe, D. et al., Virol. J. 5, 32 (2008). Application Reference: Morin, R.D., et al. Nat Genet. 2010 February; 42(2): 181-185.
Description
Mutant version of our regular EZH2 5-member complex (Cat. #51004), but with a Tyr-to-Ser mutation on a.a. 646 of the EZH2 protein. Complex of human EZH2 (GenBank Accession No. NM_004456), a.a. 2-end, Y646S*, with N-terminal His-tag, MW= 86 kDa, human EED (NM_003797), a.a. 2-end with N-terminal FLAG-tag, MW= 51 kDa, human SUZ12 (NM_015355), a.a. 2-end with N-terminal His-tag, MW = 87 kDa, Human AEBP2 (NM_153207), a.a. 2- end with N-terminal His-tag, MW= 53 kDa, and human RbAp48 (NM_005610), a.a. 2-end with N-terminal His-tag, MW = 48 kDa, co-expressed in a baculovirus expression system. - Useful for Western blot analysis and to investigate protein-protein interactions in the EZH2 complex. - Avoid freeze/thaw cycles.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
