DNA Base Excision Repair Pathway Inhibitor
CAY-16348-25 25 mg
Synonyms: 7-Nitroindole-2-Carboxylic Acid|CRT0044876|NSC 69877
Data Sheet: 
SDS:
SDS:
CAS
6960-45-8
Formulation
A crystalline solid
Purity
≥98%
MW
206,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5’ to the abasic site to produce a single strand break.{26694} DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM).{26694,26697,26696} Although not toxic to cells by itself at 200 µM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration.{26697} DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival.{26697,26695}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
