DK-AH 269
CAY-21425-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
186097-54-1
Formulation
A crystalline solid
Purity
≥98%
MW
519,1
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells).{30118} DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart.{33670} Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg.{30118} DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.{30118}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
