Cholera Toxin (azide free)
CAY-19654-1 1 mg
Synonyms: Choleragen|CT
Data Sheet: 
SDS:
SDS:
Formulation
Each vial contains 1 mg of lyophilized cholera toxin (CT). When reconstituted to 0.5 ml with water, the buffer is 0.05 M Tris, 0.2 M sodium chloride, 0.001 M disodium EDTA at pH 7.5
Purity
≥95% (estimated by SDS-PAGE)
MW
0
Shipment
4
Long Term Storage
4
Shelf Life
730
Description
Cholera toxin is produced by V. cholerae and is a multimeric enterotoxin that consists of a single A subunit surrounded by five B subunits.{31319} Following binding to the membrane of enteric cells, the toxin is endocytosed and travels to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol. Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the Gsα protein, which activates adenylate cyclase, locking it in an ‘on’ position.{31320} The increased intracellular concentration of cAMP causes hypersecretion of chloride and bicarbonate ions, which results in increased fluid secretion and severe diarrhea characteristic of the disease cholera.{31319}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
