Cetirizine (hydrochloride)
CAY-19686-25 25 g
Data Sheet: 
SDS:
SDS:
CAS
83881-52-1
Formulation
A crystalline solid
Purity
≥98%
MW
461,8
Shipment
-20
Long Term Storage
-20
Shelf Life
730
Description
Cetirizine is a bioactive carboxylated metabolite of hydroxyzine (Item No. 24039) that acts as a selective histamine H1 receptor antagonist (Ki = 10 nM).{15199,31604} As a second generation antihistamine, it is non-sedating due to low lipophilicity, which prevents blood-brain barrier transit.{31603} Cetirizine is a racemic mixture composed of equal amounts of two enantiomers, (R)-cetirizine (Item No. 23992) and (S)-cetirizine, with pharmacological activity residing primarily in the (R) isomer.{31604} Cetirizine inhibits eosinophil chemotaxis and leukotriene B4 (LTB4; Item No. 20110) release independent from H1 antagonism.{31605} It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED50 = 100 μg/kg, p.o.).{47108} Formulations containing cetirizine have been used in the treatment of allergic rhinitis and chronic urticaria.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
