CL 387,785
CAY-19081-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
194423-06-8
Formulation
A crystalline solid
Purity
≥95%
MW
381,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers.{14867} CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM).{31034} It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM).{31034} CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.{31034}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
