CGI1746
CAY-18414-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
910232-84-7
Formulation
A crystalline solid
Purity
≥98%
MW
579,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
CGI1746 is a potent, selective inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 1.9 nM), a non-receptor tyrosine kinase that is important in B lymphocyte development.{32058,30641} It blocks both auto-and trans-phosphorylation of BTK by occupying an SH3 binding pocket in the un-phosphorylated enzyme. CGI1746 prevents B-cell antigen receptor-mediated B lymphocyte proliferation and suppresses FCγRIII-induced TNFα, IL-1β, and IL-6 production in macrophages.{32058} It reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.{32058}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
