CFTR Inhibitor II
CAY-15772-25 25 mg
Synonyms: Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II|GlyH-101
Data Sheet: 
SDS:
SDS:
CAS
328541-79-3
Formulation
A crystalline solid
Purity
≥95%
MW
493,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR).{25612} CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM).{25797,25798} This compound binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport.{25797,25798} Intraluminal CFTR inhibitor II greatly reduces intestinal fluid secretion induced by cholera toxin.{25798} It is effective in cells in culture and also in nasal and intestinal epithelia in vivo.{25794,25793,25795,25796}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
