CC-92480
CAY-31065-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
2259648-80-9
Formulation
A solid
Purity
≥98%
MW
567,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
CC-92480 is a modulator of the E3 ligase cereblon.{59303} It binds to cereblon (IC50 = 0.03 µM in a FRET assay) and induces the degradation of Ikaros and Aiolos in lenalidomide-resistant H929 R10-1 cells when used at concentrations of 1, 10, and 100 nM. CC-92480 induces apoptosis in the same cells. It reduces tumor growth in an H929 R10-1 mouse xenograft model when administered at doses of 1, 3, and 10 mg/kg.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
