Bruceantin
CAY-33973-1 1 mg
Synonyms: (–)-Bruceantin|NCI 165563|NSC 165563
Data Sheet: 
SDS:
SDS:
CAS
41451-75-6
Formulation
A solid
Purity
≥95%
MW
548,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Bruceantin is a quassinoid originally isolated from B. antidysenterica that has diverse biological activities.{54980,42191,54981} It inhibits protein synthesis in HeLa cells, reticulocytes, and reticulocyte lysates (IC50s = 30, 40, and 1,600 nM, respectively).{54980} Bruceantin is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 8 and 13 nM, respectively).{42191} It induces apoptosis in HL-60 leukemia and RPMI-8226 multiple myeloma cells (IC50s = 12.2 and 12.8 nM, respectively).{54981} Bruceantin (5 mg/kg) induces tumor regression in an RPMI-8226 mouse xenograft model.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
