Bestatin (hydrochloride)
CAY-70520-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
65391-42-6
Formulation
A crystalline solid
Purity
≥98%
MW
344,8
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli.{33261} It inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM).{33261,48771,91} It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin.{33261} Bestatin inhibits the production of LTB4 (Item No. 20110) in erythrocytes when used at a concentration of 70 µM.{91} It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells.{48772} Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.{48773}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
