BLU-782
CAY-35490-10 10 mg
Synonyms: Activin Receptor-like Kinase 2 Inhibitor 1|ALK2-IN-1|Fidrisertib
Data Sheet: 
SDS:
SDS:
CAS
2141955-96-4
Formulation
A solid
Purity
≥95%
MW
562,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
BLU-782 is an inhibitor of activin receptor-like kinase 2 (ALK2) containing an arginine-to-histidine substitution mutation at position 206 (ALK2R206H), an activating mutation found in patients with fibrodysplasia ossificans progressiva (FOP), which is characterized by progressive heterotopic ossification, or diffuse intrinsic pontine glioma (DIPG), which is a type of pediatric brain stem cancer.{68018} It binds to ALK2R206H (IC50 = ≤10 nM) and reduces phosphorylation of the ALK2 substrate SMAD1 at serine 463 (Ser463) and Ser465 in HEK293 cells expressing ALK2R206H (IC50 = ≤100 nM).
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
