BCMA Antibody / CD269 / TNFRSF17
NSJ-V4423-100UG 100 ug
Data Sheet: 
Reactivity
Human
Applications
ELISA, IHC-P
Source / Host
Rabbit
Immunogen
A recombinant human protein fragment (within amino acids 1-184) was used as the immunogen for the recombinant BCMA antibody.
Clone
CD269/7986R
Purity
Protein A/G affinity
Long Term Storage
Aliquot the recombinant BCMA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Description
The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
