Azurocidin, Human, ELISA kit
HYC-HK352-01 1 x 96 det.
Synonyms: cationic antimicrobial protein CAP37, heparin-binding protein, HBP
Data Sheet: 
SDS:
SDS:
Reactivity
Human
Assay Range
Measurable concentration range of 1.6 to 100 ng/ml.
Sensitivity
Minimum concentration which can be measured is 1.6 ng/ml.
Shelf Life
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least six months.
Description
Azurocidin, also called heparin-binding protein (HBP) or cationic antimicrobial protein of 37 Kda (CAP37), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C.albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulator of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via β2-intergrins.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
