Azadiradione
CAY-37063-1 1 mg
Data Sheet: 
CAS
26241-51-0
Formulation
A solid
Purity
≥98%
MW
450,6
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
A limonoid with diverse biological activities; inhibits heparin-induced tau aggregation by 54.2% in a cell-free assay at 400 µM; inhibits the tautomerase activity of human, P. falciparum, and P. yoelii MIF (IC50s = 35.2, 45.6, and 43 µM, respectively); cytotoxic to HL-60 leukemia and SK-BR-3 breast cancer cells (IC50s = 14.7 and 15.9 µM, respectively) but not A549 lung, AZ-521 stomach, or CRL-1579 melanoma cells (IC50s = >20 µM for all); decreases the mutant huntingtin aggregate load in the cortex, striatum, and hippocampus, improves motor function, and increases lifespan in the R6/2 transgenic mouse model of Huntington’s disease at 10 mg/kg; reduces blood glucose levels and α-amylase activity, as well as serum triglyceride and HDL levels, in a rat model of streptozotocin-induced diabetes at 10 mg/kg
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
