Anti-Human ADAM-10, made in Mouse
REL-101-M205 100 µg
Synonyms: ADAM10; kuz; AD10; MADM; CD156c; HsT18717
Reactivity
Anti-Human
Applications
WB
Source / Host
Mouse
Clone
(#6D31)
IsoType
IgG2
Shipment
RT
Long Term Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Description
The monoclonal antibody reacts with human CD156c, which is also known as a disintegrin and metalloproteinase domain-containing protein (ADAM) 10. This type I transmembrane glycoprotein is expressed ubiquitously on hematopoietic and non-hematopoietic cell types. Studies demonstrate that CD156c expression is regulated by PAX2 in cancer cells. CD156c plays a critical role in hematopoiesis, including lymphocyte development, and autoimmunity by regulating the shedding and secretion of various receptors and chemokines, including Notch, CD23, CXCL16, and the IL-6R. Finally, deregulated CD156c expression has been associated with T-cell acute lymphoblastic lymphoma (T-ALL) and Alzheimer’s disease.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
