Anti-DGCR8 (Ser377) Antibody
ABI-p1035-377 100 µL
Synonyms: DGCRK6 antibody, C22orf12 antibody, D16H22S788E antibody, D16Wis2 antibody, DGCR 8 antibody, Dgcr8 antibody, DGCR8 microprocessor complex subunit antibody, DGCR8_HUMAN antibody, DGCRK 6 antibody, DiGeorge syndrome critical region 8 antibody, DiGeorge synd
Data Sheet: 
Reactivity
Human and Mouse
Applications
ELISA, WB
Concentration
Lot Dependent
Shipment
Blue Ice
Long Term Storage
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Shelf Life
After date of receipt, stable for at least 1 year at -20°C.
Description
Our Anti-DGCR8 (Ser377) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects human and mouse DGCR8 (Ser377) and is antigen affinity purified from pooled serum. It is great for use in WB. - The Drosha-DGCR8 microprocessor complex is required for microRNA (miRNA) biogenesis. DGCR8 (DiGeorge Syndrome Critical Region 8) recognizes the RNA substrate, whereas Drosha functions as the endonuclease. DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains, interacts with the pri-miRNA and functions as the molecular anchor that measures the distance from the ds-RNA-ssRNA junction and directs Drosha cleavage 11bp away (Han, J., et al, 2006). The efficiency of Drosha cleavage increases in the presence of heme and promotes the formation of highly ordered DGCR8 structures upon binding to RNA (Faller, M., et al, 2010). -
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
