Alternariol
BVT-0465-M001 1 mg
Data Sheet: 
SDS:
SDS:
CAS
641-38-3
Purity
>98% (HPLC)
Shipment
Ambient
Short Term Storage
+4°C
Long Term Storage
+4°C
Shelf Life
Stable for at least 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C.
Description
Chemical. CAS: 641-38-3. Formula: C14H10O5. MW: 258.2. Isolated from Alternaria sp. Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIalpha in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3beta inhibitor (sub-µM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
