AZD 4604
CAY-39890-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
2241039-81-4
Formulation
A solid
Purity
≥98%
MW
599,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
AZD 4604 is a JAK1 inhibitor (IC50 = 0.54 nM).{66652} It is selective for JAK1 over JAK2 and JAK3 (IC50s = 686 and >10,000 nM, respectively), as well as tyrosine kinase 2 (TYK2; IC50 = 657 nM). AZD 4604 inhibits IL-4- or IL-13-induced phosphorylation of STAT6 in U937 cells (IC50s = 24 and 34 nM, respectively). In vivo, AZD 4604 (1 mg/kg) reduces lung STAT3 and STAT5 phosphorylation in a rat model of ovalbumin-induced asthma.{66653} It also inhibits lung eosinophilia and reduces the late asthmatic response in the same model.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
