APS-2-79 (hydrochloride)
CAY-22137-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
2002381-31-7
Formulation
A crystalline solid
Purity
≥95%
MW
423,9
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR).{45098} It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes.{45098,45099} APS-2-79 (5 μM) inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells.{45098} It enhances the efficacy of the MEK inhibitor trametinib (Item No. 16292), further reducing cell viability in HCT116 and A549 cell lines containing K-Ras mutations, but not B-RAF mutant SK-MEL-239 and A375 cell lines, when used at a concentration of 1 μM.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
