AM92016 (hydrochloride)
CAY-36803-50 50 mg
Data Sheet: 
SDS:
SDS:
CAS
133229-11-5
Formulation
A solid
Purity
≥98%
MW
483,8
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
AM92016 is an inhibitor of delayed-rectifier potassium current (IKr; IC50 = 40 nM in isolated rabbit sinoatrial node cells).{65349} It is selective for IKr over L-type voltage-gated calcium (Cav) current and hyperpolarization-activated inward current (If) at 1 µM. AM92016 (50 nM) decreases the diastolic depolarization rate and increases cycle length and action potential duration at full repolarization in isolated rabbit sinoatrial node cells. It decreases the QT interval and increases heart rate in anesthetized guinea pigs when administered at a dose of 1 mg/kg.{65350} AM92016 (1 mg/kg) decreases the time to first arrhythmia and ventricular fibrillation in ouabain-stimulated guinea pigs.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
