6-Thioguanine
V13-14126 1 g
Synonyms: DNMT, DNA methylation, inhibitor, methylation, 6-thioguanine, cytosine, 5mC
Data Sheet: 
Shipment
Room Temp
Short Term Storage
-20C
Long Term Storage
Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month.
Description
After incorporation into DNA, Active Motif's 6-Thioguanine disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1). 6-Thioguanine incorporates into DNA and induces double-strand breaks which destabilize DNA structure resulting in cytotoxicity. It selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in xenograft model. It has anti-cancer and immunosuppressive activity.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
