5-Azacytidine
V13-14103 50 mg
Data Sheet: 
Shipment
Room Temp
Short Term Storage
-20C
Long Term Storage
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
Description
Active Motif's 5-Azacytidine is a specific and potent inhibitor of DNA methyltransferase, DNMT1. It acts as a suicide substrate for methyltransferases after incorporation into DNA, and induces apoptosis in HCT-116 colon cancer cells that is mediated by p53 and its downstream effectors p21 (WAF1) and GADD45. 5-Azacytidine increases stem cell reprogramming efficiency, induces cardiac differentiation of human umbilical cord-derived MSCs, and reverses drug resistance in bladder cancer cells. It is an antileukemic agent that is cell permeable.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
