4-amino-1,8-Naphthalimide
CAY-18509-50 50 mg
Synonyms: 4-Aminonaphthalimide|4-ANI
Data Sheet: 
SDS:
SDS:
CAS
1742-95-6
Formulation
A crystalline solid
Purity
≥95%
MW
212,2
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.{22577,22591} 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM).{22573} It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation.{29753} 4-ANI is used to study the role of PARP activity in various cell systems.{25755,29751,29752}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
