3CL Protease (MERS-CoV) Inhibitor Screening Assay Kit
BPS-78278 96 rxns.
Data Sheet: 
Applications
Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Shipment
-80°C (dry ice)
Literature References
Kankanamalage A., et al., Eur. J. Med. Chem. 2018, 150: 334-346.
Description
The 3CL Protease (MERS-CoV) Inhibitor Screening Assay Kit is designed to measure 3CL Protease activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps. A protease inhibitor cocktail is included as a positive control. Assay Principle: 3CL Protease (MERS-CoV) Assay Kit uses a custom-synthesized peptide which has a fluorescence group quenched by a specific quencher. This peptide works as a substrate for 3CL Protease (MERS-CoV). After proteolytic cleavage, fluorescence product is formed and detected at λexcitation=485 nm and λemission=528 nm.
Middle East Respiratory Syndrome coronavirus (MERS-CoV) poses a significant threat to public health worldwide due to its ability to cause serious human disease with high mortality rates. MERS-CoV has become a global threat due to continuous outbreaks in countries on the Arabian Peninsula and the potential for spread to other countries. MERS-CoV 3CL protease is essential for viral replication; consequently, it is an attractive target for small molecule therapeutics.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
