1-Deoxynojirimycin (hydrochloride)

  CAY-10011718-10 10 mg

Data Sheet:     SDS:    

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73285-50-4  

A crystalline solid  

≥95%  

199,6  

-20  

-20  

1460  

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Description

 

1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities.{63324,63325,16721,16270,63326,63327} It inhibits the activities of α- and β-glucosidase (IC50s = 35 and 71 µM, respectively).{63325} 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells.{16721} It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM.{16270} 1-DNJ (1-100 µg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells.{63326} It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.{63327}

 

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