(±)-Necrostatin-2
CAY-20924-10 10 mg
Synonyms: (±)-Nec-2|7-chloro-O-Nec-1|7-Cl-O-Nec-1|7-Cl-O-Necrostatin-1|Nec-1s|Necrostatin-1s
Data Sheet: 
SDS:
SDS:
CAS
852391-15-2
Formulation
A crystalline solid
Purity
≥98%
MW
277,7
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
(±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner.{33477} Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS). (±)-Necrostatin-2 decreases irradiation-induced lactate dehydrogenase (LDH) release and cell death in murine embryonic Cyt c-/- cells.{38080} It also prevents angiotensin II-induced elastin degradation and aortic inflammation in a murine abdominal aortic aneurism (AAA) model at a dose of 1.6 mg/kg/day.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
