(-)-Epigallocatechin gallate
CDX-E0128-M010 10 mg
Data Sheet: 
CAS
989-51-5
Purity
>98% (HPLC)
Shipment
Ambient
Short Term Storage
+20°C
Long Term Storage
-20°C
Shelf Life
Stable for at least 2 years after receipt when stored at +4°C.
Description
Chemical. CAS: 989-51-5. Formula: C22H18O11. MW: 458.37. (-)-Epigallocatechin gallate (EGCG), an antioxidant and anti-inflammatory polyphenol flavonoid exerts antitumor properties by inhibiting telomerase and DNA methyltransferase activity. EGCG inhibits the expression of matrix metalloproteinase-2 (MMP-2), MMP-9 and reduces the invasiveness. EGCG blocks the activation of epidermal growth factor (EGF) receptors and human epidermal growth factor receptor-2 (HER-2). Regulates cancer cell growth, proliferation, transformation, survival, angiogenesis, apoptosis, invasion and metastasis. EGCG increases bone mineral density and reduces bone resorption. EGCG inhibits osteoclastogenesis by inhibiting receptor activator of nuclear factor kappaB ligand (RANKL) induced nuclear factor kappa B (NF-kappaB) transcriptional activity. EGCG has neuroprotective and anti-aging property and increases myogenic differentiation. EGCG inhibits fatty acid synthase and glutamate dehydrogenase activity. EGCG has preventive cardiovascular and metabolic (obesity, insulin resistance, hypertension and hypercholesterolemia) effects and in vivo, EGCG reduces food intake and body weight, serum levels of insulin, leptin, testosterone and growth hormone.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
