(-)-Deguelin
CAY-10010706-10 10 mg
Data Sheet: 
SDS:
SDS:
CAS
522-17-8
Formulation
A crystalline solid
Purity
≥98%
MW
394,4
Shipment
-20
Long Term Storage
-20
Shelf Life
48 months
Description
(−)-Deguelin is a rotenoid that has been found in T. vogelii and has diverse biological activities.{51433,16334,16332,16314} It inhibits mitochondrial complex I, also known as NADH dehydrogenase, activity in bovine heart electron transport particles and phorbol 12-myristate 13-acetate-induced ornithine decarboxylase (ODC) activity in MCF-7 breast cancer cells (IC50s = 6.9 and 11 nM, respectively).{16334} (−)-Deguelin (100 nM) induces apoptosis in MCF-7 and SK-BR-3 breast cancer cells.{16332} It induces mortality in adult bruchid beetles (C. maculatus) when used at concentrations ranging from 10 to 500 ppm.{51433} (−)-Deguelin (6 mg/kg) induces nigrostriatal dopaminergic degeneration in rats.{16314}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
