(−)-Caryophyllene oxide
CAY-21573-1 1 g
Data Sheet: 
SDS:
SDS:
CAS
1139-30-6
Formulation
A crystalline solid
Purity
≥98%
MW
220,4
Shipment
-20
Long Term Storage
-20
Shelf Life
48 months
Description
(–)-Caryophyllene oxide is a bicyclic sesquiterpene and a metabolite of β-caryophyllene that has been found in C. sativa and has anticancer properties.{34255,34256} Unlike β-caryophyllene, (−)-caryophyllene oxide does not bind to the cannabinoid (CB) receptor CB2 (Ki = >20 µM). It induces calcium currents in HL-60 cells expressing CB2 receptors but also does so in CB2-deficient cells. (−)-Caryophyllene oxide is cytotoxic to HepG2, AGS, HeLa, SNU-1 and SNU-16 cells (IC50s = 3.95, 12.6, 13.55, 16.79, and 27.39 µM, respectively).{37661} It is the volatile component of C. sativa sensed by narcotic detection dogs.{34255} Formulations containing (–)-caryophyllene have been used as flavoring agents.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
