(–)-Chaetominine
CAY-13135-2.5 2.5 mg
Data Sheet: 
SDS:
SDS:
CAS
918659-56-0
Formulation
A solid
Purity
≥95%
MW
402,4
Shipment
-20
Long Term Storage
-20
Shelf Life
48 months
Description
(–)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015.{43151} It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (–)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9.{43152} It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin (Item No. 15007) in resistant K562 cells.{43153}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
