(±)-Verapamil . hydrochloride (USP Grade)
AG-CR1-3627-G005 5 g
Data Sheet: 
SDS:
SDS:
Source / Host
Synthetic.
CAS
152-11-4
Purity
>99% (NMR)
MW
454.6 . 36.5
Shipment
AMBIENT
Short Term Storage
+4°C
Long Term Storage
+4°C
Shelf Life
Stable for at least 2 years after receipt when stored at +4°C.
Description
Chemical. CAS: 152-11-4. Formula: C27H38N2O4 . HCl. MW: 454.6 . 36.5. Synthetic. alpha1-Adrenergic receptor (alpha-AR) antagonist. Prototypical calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Vasodilator known to reduce the renal clearance of digoxin and used to control hypertension, angina, cardiac arrhythmia and vascular headaches. Apoptosis inducer in primary and metastatic colon adenocarcinoma human cell lines in vitro. Inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein) which are often over-expressed in certain tumor cell lines. Substrate of CYP3A4 and CYP2C6. Used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Anti-diabetic in animal models by limiting TXNIP expression.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
