(−)-Cotinine
CAY-15314-250 250 mg
Data Sheet: 
SDS:
SDS:
CAS
486-56-6
Formulation
A crystalline solid
Purity
≥98%
MW
176,2
Shipment
-20
Long Term Storage
-20
Shelf Life
48 months
Description
(–)-Cotinine is an alkaloid that has been found in tobacco plants and an active metabolite of the neuronal nicotinic acetylcholine receptor (nAChR) agonists (±)-nicotine (Item No. 16535) and (–)-nicotine (Item Nos. 29138 | 20887).{24960,26185} It is formed from nicotine by the cytochrome P450 (CYP) isoforms CYP2A6 or CYP2A13 via a 5'-hydroxy nicotine intermediate.{26185} (–)-Cotinine (1 and 10 µM) reduces the number of dsDNA breaks induced by the tobacco-specific nitrosamine carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; Item No. 16414) in a comet assay using HepaRG hepatocellular carcinoma cells.{26723} In vivo, (–)-cotinine (0.09 µg/kg) increases nicotine self-administration in rats.{20194}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
