Vinci-Biochem Srl
Via Ponte di Bagnolo, 10
50059 Vinci (Firenze) Italy
vb@vincibiochem.it
Tel:+39 0571 568 147 -
 0571 568 135
Fax:+39 0571 568132 - P. IVA 05706610481

Ubiquitin-Proteasome Pathway (UPP)


   

 

South Bay Bio
South Bay Bio LLC, formed in 2016, provides expertise in the ubiquitin proteasome system (UPS) and other innovative research areas, like UPS related assay development, HTS, protein purification, bioconjugation and custom biochemistry services.
Autophagy Ubiquitination Cayman
Autophagy & The Ubiquitin-Proteasome Pathway
Recycling the Cell: Autophagy and the Ubiquitin-Proteasome Processes
20S Proteasome Assay Kit
Ubiquitinated Protein Detection
DUB Activity Assay Kit
Ubiquitin Interact Kit
Ubiquitinated Protein Capture Kit
Ubiquitin Link Kit
       
Ubiquitin Proteasome AdipoGen Ubiquitin Proteasome Research: AdipoGen® Flyer_Adipogen_Autophagy_2014
Flyer Adipogen Autophagy
       
Ubiquitin_Flyer
Ubiquitin Proteasome Pathway Products: Biovision
Assay Kits
Antibodies
Enzymes
Inhibitors
Substrates
Polyubiquitinated-Proteins
Polyubiquitinated Proteins Extraction/Enrichment/Detection: Biovision
EZEnrich™ Polyubiquitin Beads 
EZDetect™ Polyubiquitin Probe (Biotin conjugated) 
EZExtract™ Polyubiquitin Buffer Kit 
UIM-UBA Fusion Protein 
Multipurpose Mini Spin Columns
       
       

 

The ubiquitin-proteasome pathway (UPP) is the primary cytosolic proteolytic machinery for the selective degradation of various forms of damaged proteins. Proteins tagged by ubiquitination (e.g., attachment of ubiquitin to the target molecule) are degraded in the proteasome, a complex intracellular structure composed of multiple enzymatic complexes, presiding over protein catabolism. The end products of its activity are, in fact, small peptides suitable for antigen presentation or amino acid residues that can be recycled within the cell.

The ubiquitin-proteasome system (UPS) has been increasingly recognized as a major system involved in several biological processes such as cell proliferation, adaptation to stress and cell death. The critical role that the Ubiquitin Proteasome Pathway (UPP) plays in cellular signaling coupled with increasing validation of the therapeutic potential of targets in this pathway is accelerating interest in this field among both academic and pharmaceutical researchers. 
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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    Vinci-Biochem Srl
    Via Ponte di Bagnolo, 10
    50059 Vinci (Firenze) Italy
    vb@vincibiochem.it
    Tel:+39 0571 568147
    Fax:+39 0571 568132
    P. IVA 05706610481