Vinci-Biochem Srl
Via Ponte di Bagnolo, 10
50059 Vinci (Firenze) Italy
vb@vincibiochem.it
Tel:+39 0571 568 147 -
 0571 568 135
Fax:+39 0571 568132 - P. IVA 05706610481

Ubiquitin-Proteasome Pathway (UPP)


Protein homeostasis at the cellular level is precisely balanced by de-novo synthesis, post-translational modifications and proteolytic degradation. Protein degradation serves several functions including the elimination of damaged and no longer needed proteins, activation of protein precursors by partial hydrolysis or the complete hydrolysis of proteins that regulate multiple functions. The majority (>80%) of all mammalian proteins are degraded by the ubiquitin proteasome system (UPS). Over the past decade, knowledge about the UPS has exploded. It has now become obvious that the ubiquitination of proteins does not solely target them for degradation, but can also play a role in regulatory functions including translational regulation, activation of transcription factors and kinases, DNA repair, endocystosis and vesicular transport of membrane proteins.

   

 

South Bay Bio
South Bay Bio LLC, formed in 2016, provides expertise in the ubiquitin proteasome system (UPS) and other innovative research areas, like UPS related assay development, HTS, protein purification, bioconjugation and custom biochemistry services.
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    Vinci-Biochem Srl
    Via Ponte di Bagnolo, 10
    50059 Vinci (Firenze) Italy
    vb@vincibiochem.it
    Tel:+39 0571 568147
    Fax:+39 0571 568132
    P. IVA 05706610481