Dapiprazole (hydrochloride)
CAY-29222-250 250 mg
Data Sheet: 
SDS:
SDS:
CAS
72822-13-0
Formulation
A crystalline solid
Purity
≥98%
MW
361,9
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
Dapiprazole is an α-adrenergic receptor (α-AR) antagonist.{48750} It inhibits norepinephrine-induced contractions in rat vas deferens, guinea pig spleen, and rat aorta, regions that express high levels of α1A-AR, α1B-AR, and α1D-ARs, respectively (pA2s = 7.93, 7.13, and 8.26, respectively). It also inhibits contractions induced by histamine, angiotensin II, pentagastrin (Item No. 28546), carbamoylcholine (carbachol; Item No. 14486), and serotonin (Item No. 14332) in guinea pig ileum in a dose-dependent manner.{48751} Dapiprazole (0.05%, intracameral) reverses pupil dilation induced by a combination of the α1A-AR agonist phenylephrine and the muscarinic M4 antagonist tropicamide (Item No. 16606) in rabbits.{48752} Formulations containing dapiprazole have been used in the treatment of iatrogenically induced mydriasis by adrenergic or parasympatholytic agents in certain eye examinations.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
