BRD6989
CAY-35358-25 25 mg
Data Sheet: 
SDS:
SDS:
CAS
642008-81-9
Formulation
A solid
Purity
≥98%
MW
264,3
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
BRD6989 is an inhibitor of the Cdk8/cyclin C complex.{69055} It selectively binds to the Cdk8/cyclin C complex (IC50 = ~200 nM) over the Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p35, Cdk7/cyclin H, and Cdk9/cyclin T complexes at 1,000 nM. BRD6989 increases the production of IL-10 in primary mouse bone marrow-derived dendritic cells (BMDCs) stimulated with zymosan A (Item No. 21175) with an EC50 value of approximately 1 µM and reduces zymosan A-induced increases in IL-6 levels in the same cells.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
