Astilbin

  CAY-28267-5 5 mg

Data Sheet:     SDS:    

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29838-67-3  

A crystalline solid  

≥98%  

450,4  

-20  

-20  

1460  

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Description

 

Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities.{48502,48503,48504} It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM.{48502} Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson's disease when administered at a dose of 50 mg/kg per day.{48503} Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson's disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM.{48504} Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.

 

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