ABP 688
CAY-30929-5 5 mg
Data Sheet: 
SDS:
SDS:
CAS
924298-51-1
Formulation
A solid
Purity
≥98%
MW
240,3
Shipment
-20
Long Term Storage
-20
Shelf Life
1460
Description
ABP 688 is a non-competitive antagonist of metabotropic glutamate receptor 5 (mGluR5; Ki = 3.5 nM in a radioligand binding assay using L(tk-) cell membranes expressing human receptors).{53878} It is selective for mGluR5 receptors over a panel of CNS G protein-coupled receptors, ion channels, and transporters at 10 μM. ABP 688 inhibits quisqualate-induced phosphoinositol accumulation in and glutamate-induced calcium release from L(tk-) cells expressing human mGluR5 (IC50s = 2.4 and 2.3 nM, respectively). Radiolabeled forms of ABP 688 have been used as PET tracers for in vivo imaging of mGluR5 receptors in rodents.{53878,53879}
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
