AACT Antibody / Alpha-1-Antichymotrypsin / SERPINA3
NSJ-V9447-100UG 100 ug
Data Sheet: 
Reactivity
Human
Applications
IHC-P
Source / Host
Mouse
Immunogen
A portion of amino acids A portion of amino acids 49-187 was used as the immunogen for the AACT antibody.
Clone
SERPINA3/4184
Purity
Protein A/G affinity
Long Term Storage
Aliquot the AACT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Description
It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
ESCLUSIVAMENTE PER USO DI RICERCA (RUO) e non per uso terapeutico o diagnostico su uomini o animali. Il prodotto NON è un Dispositivo Medico o un Diagnostico in Vitro.
PRODUCT FOR RESEARCH USE ONLY (RUO) and not for therapeutic or diagnostic use on humans or animals. The product is NOT a Medical Device or an In-Vitro Diagnostic (IVD).
