Resistin
The adipocytokine resistin which belongs to a family of cysteine-rich C-terminal proteins known as resistin-like molecules (RELM; RELM-α/FIZZ 1 and RELM-β/FIZZ 2) of FIZZ (found in inflammatory zone) are thought to be involved in inflammatory processes. Previous studies in mice showed that resistin impairs glucose tolerance and insulin action. In addition, resistin also inhibits adipogenesis in murine 3T3-L1 cells. Therefore resistin has also been proposed as an adipocyte-secreted factor thought to link obesity and T2DM.
Resistin (human) (rec.)
AG-40A-0010Y-C010 10 µg
AG-40A-0010Y-C050 50 µg
Product References
Expression of resistin in the prostate and its stimulatory effect on prostate cancer cell proliferation: H.J. Kim, et al.; BJU Int. 108: 1464 (2010)
Product Datasheet
|
|
|
Synonyms |
FIZZ3; Found in Inflammatory Zone 3; ADSF; Adipose Tissue-Specific Secretory Factor |
|
Properties |
|
Source/Host |
HEK 293 cells |
|
Sequence |
Human resistin (aa 19-108) is fused at the N-terminus to a FLAG®-tag. |
|
Crossreactivity |
Human |
|
Biological Activity |
Inhibits insulin-stimulated glucose uptake in L6 skeletal muscle cells. |
|
MW |
~13kDa (SDS-PAGE) |
|
Purity |
≥95% (SDS-PAGE) |
|
Endotoxin Content |
<0.01EU/μg purified protein (LAL test; Lonza). |
|
Concentration |
After reconstitution:
for 10µg size: 0.1mg/ml
for 50µg size: 1 mg/ml |
|
Reconstitution |
10µg size: Reconstitute with 100µl sterile water.
50µg size: Reconstitute with 50µl sterile water.
PBS containing at least 0.1% BSA should be used for further dilutions. |
|
Formulation |
Lyophilized. Contains PBS. |
|
Other Product Data |
UniProt link Q9HD89: Resistin (human) (precursor)
FLAG is a registered trademark of Sigma-Aldrich Co.
|
|
Product Type |
Protein |
|
Shipping and Handling |
|
Shipping |
BLUE ICE |
|
Short Term Storage |
+4°C |
|
Long Term Storage |
-20°C |
|
Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
|
Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. |
|
Related Products |
|
|