Vinci-Biochem Srl
Via Ponte di Bagnolo, 10
50059 Vinci (Firenze) Italy
Tel: +39  0571 568 147 e 0571 568 135
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Progranulin

Crescente interesse per questa proteina da parte dei Ricercatori impegnati nelle malattie neurodegenerative e non solo:

 
• Frontotemporal Lobar Degeneration (FTLD) 
• Huntingdon's disease
• Metabolism
• Alzheimer’s Disease (AD) 
• Schizophrenia
• Bipolar disorder (BPD) 
• Semantic Dementia (SD) 
• Progressive Non-Fluent Aphasia (PNFA)
• Alzheimer's disease (AD)
• Visceral Obesity, Elevated Plasma Glucose, and Dyslipidemia 
• Wound Healing
• Cartilage Repair
• Inflammation/Neuroinflammation Modulator
• Mitogenic and Tumor Promoting Effects
• Breast Cancer 
• Epithelial Ovarian Cancer (EOV) 
• Hepatocellular Carcinoma (HCC) 
• Cholangiocarcinom (CCA) 
• Nonalcoholic Fatty Liver Disease (NAFLD) 
 

ADIPOGEN

 

 

Adipogen Progranulin

Tag-free Progranulins – Unique Tools for in vivo Research

 
• Higher activity compared to tagged Progranulins
• Suitable for in vitro and in vivo studies
• Reflects the native sequence with no additional amino acids
• Correct processed protein (at the N-terminus)
• Affinity purified
• Low endotoxin levels (<0.1EU/μg)

 

Scarica PDF
 
 

 Progranulin [PGRN] ELISA Kits

 

NEW Progranulin (human) ELISA Kit (mAb/mAb)
Reliable & Cost-effective

 AG-45B-0027-KI01
Progranulin (human) ELISA Kit  AG-45A-0018Y
Progranulin (mouse) ELISA Kit AG-45A-0019Y
Progranulin (rat) ELISA Kit AG-45A-0043Y
 
 
• Trusted Reproducible Results!
• Used to Determine Cut-Off values for FTLD!
• Cited in Hundreds of Scientific Publications!

 

TAG-FREE - Progranulin Recombinant Proteins

 

• Higher activity compared to tagged progranulins

• Suitable for in vitro and in vivo studies
• Reflects the native sequence with no additional amino acids
• Affinity purified
• Low endotoxin levels (<0.01EU/µg)

 

 

 

Progranulin Antibodies, Tagged Proteins & Related Products

 

Product Name PID Product Description

anti-Progranulin (human), pAb

AG-25A-0112

 Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F. Works in Immunohistochemistry and Western blot applications.

anti-Progranulin (mouse), pAb

AG-25A-0093

 Recognizes mouse progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with human progranulin. Works in Western blot application.
anti-Granulin C (human), pAb AG-25A-0090 Recognizes human granulin C. Detects a band of ~12kDa by Western blot. Cross-reacts with human progranulin. Works on recombinant protein in Western blot application.
Progranulin (human) (rec.) AG-40A-0068Y

Human progranulin (aa 1-593) is fused at the C-terminus to a FLAG®-tag. Activates ERK phosphorylation in THP-1 and MCF10A cells and induces cell migration of THP-1 monocytic leukemia cells.
Progranulin (rat) (rec.) AG-40A-0194 Rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.
Granulin C (human) (rec.) (His) AG-40A-0129

Human granulin C (aa 364-430) is fused at the N-terminus to a His-tag.
 
 
 
Selected Review Articles
 
• Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration: R. Ghidoni, et al.; Neurology 71, 1235 (2008)
• Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008)
• The granulin gene family: from cancer to dementia: A. Bateman & H.P. Bennett; Bioassays 31, 1245 (2009)
• Serum biomarker for progranulin-associated frontotemporal lobar degeneration: K. Sleegers, et al.; Ann. Neurol. 65, 603 (2009)
• The molecular basis of frontotemporal dementia: M. Neumann, et al.; Expert Rev. Mol. Med. 11, (2009)
• Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update: I.R. Mackenzie, et al.; Acta Neuropathol. 119, 1 (2010)
• Sorting out frontotemporal dementia? J. Lewis & T.E. Golde; Neuron 68, 601 (2010)
• Structure, function, and mechanism of progranulin; the brain and beyond: H. Toh, et al.; J. Mol. Neurosci. 45, 538 (2011)
• Cellular effects of progranulin in health and disease: L. De Muynck & P. Van Damme; J. Mol. Neurosci. 45, 549 (2011)
• Progranulin and TDP-43: Mechanistic Links and Future Directions: S. Kumar-Singh; J. Mol. Neurosci. 45, 561 (2011)
• Progranulin: A promising therapeutic target for rheumatoid arthritis: C.J. Liu; FEBS Lett. 585, 3675 (2011)
• Progranulin: A growth factor, a novel TNFR ligand and a drug target: C.J. Liu & X. Bosch; Pharmacol. Ther. (2011)
• Optimal Plasma Progranulin Cutoff Value for Predicting Null Progranulin Mutations in Neurodegenerative Diseases: A Multicenter Italian Study: R. Ghidoni, et al.; Neurodegener. Dis. (2011)
• Frontotemporal Lobar Degeneration. Adv Exp Med Biol. Premi E, Padovani A, Borroni B. (2012)
• Behavioral Genetics of Neurodegenerative Disorders. Galimberti D, Scarpini E. Curr Top Behav Neurosci. (2012)
• Losing protein in the brain: the case of progranulin. Ghidoni R, , et al., Brain Res. (2012)
• TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.Colombrita C., et al., J Biol Chem. (2012)
• Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. Galimberti D, et al., Reif A. PLoS One. (2012)
• Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian study.Ghidoni R., et al., Neurodegener Dis. (2012)
• Genetics of frontotemporal lobar degeneration. Galimberti D, Scarpini E. Front Neurol. (2012)
• Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Galimberti D., et al., Neurol Sci. (2012)
• Clinical phenotypes and genetic biomarkers of FTLD. Galimberti D, Scarpini E. J Neural Transm. (2012)
• Frontotemporal lobar degeneration: current knowledge and future challenges. Cerami C., et al., J Neurol. (2012)
• Prevalence of frontotemporal lobar degeneration in an isolated population: the Vallecamonica study. Gilberti N., et al., Neurol Sci. (2012)
• Circulating progranulin as a biomarker for neurodegenerative diseases. Ghidoni R., et al., Am J Neurodegener Dis. (2012)
• The progranulin (GRN) Cys157LysfsX97 mutation is associated with nonfluent variant of primary progressive aphasia clinical phenotype. Caso F., et al., J Alzheimers Dis. (2012)
• Gender Effects on Plasma PGRN Levels in Patients with Alzheimer's Disease: A Preliminary Study. Piscopo P., et al., J Alzheimers Dis. (2013)
• Estimating the age of the most common Italian GRN mutation: walking back to Canossa times. Benussi L., et al., J Alzheimers Dis. (2013)
 
 
 

ProductCodeSizePrice € Preventivo / Ordina
(−)-(8,8-DICHLOROCAMPHORYLSULFONYL) OXAZIRIDINE
CAS:
139628-16-3
Purity:
≥95% (HPLC)
SDS:
 CDX-D0021-G005 5 g inquire  
(−)-(8,8-DICHLOROCAMPHORYLSULFONYL) OXAZIRIDINE
CAS:
139628-16-3
Purity:
≥95% (HPLC)
SDS:
 CDX-D0021-G025 25 g inquire  
(−)-(Α)-KAINIC ACID (HYDRATE)
CAS:
58002-62-3
Purity:
≥98%
SDS:
 CAY-78050-10 10 mg inquire  
(−)-(Α)-KAINIC ACID (HYDRATE)
CAS:
58002-62-3
Purity:
≥98%
SDS:
 CAY-78050-25 25 mg inquire  
(−)-(Α)-KAINIC ACID (HYDRATE)
CAS:
58002-62-3
Purity:
≥98%
SDS:
 CAY-78050-5 5 mg inquire  
(−)-(Α)-KAINIC ACID (HYDRATE)
CAS:
58002-62-3
Purity:
≥98%
SDS:
 CAY-78050-50 50 mg inquire  
(–)-2-FLUORODEOXYARBUTIN
Purity:
≥98%
SDS:
 CAY-9001105-1 1 mg inquire  
(–)-2-FLUORODEOXYARBUTIN
Purity:
≥98%
SDS:
 CAY-9001105-5 5 mg inquire  
(-)-AGELOXIME D
Alternative Names:
(-)-Agelasine D oxime
CAS:
1219817-25-0
Purity:
>97% (HPLC)
SDS:
 AG-CN2-0016-M001 1 mg inquire  
(-)-ALTENUENE
CAS:
889101-41-1
Purity:
≥98%
SDS:
 CAY-21130-1 1 mg inquire  
(−)-APOMORPHINE (HYDROCHLORIDE HYDRATE)
CAS:
58117-94-5
Purity:
≥95%
SDS:
 CAY-16094-10 10 mg inquire  
(−)-APOMORPHINE (HYDROCHLORIDE HYDRATE)
CAS:
58117-94-5
Purity:
≥95%
SDS:
 CAY-16094-100 100 mg inquire  
(−)-APOMORPHINE (HYDROCHLORIDE HYDRATE)
CAS:
58117-94-5
Purity:
≥95%
SDS:
 CAY-16094-50 50 mg inquire  
(-)-ARCTIGENIN
Alternative Names:
(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone
CAS:
7770-78-7
Purity:
>99% (HPLC)
SDS:
 AG-CN2-0530-M010 10 mg inquire  
(-)-ARCTIGENIN
Alternative Names:
(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone
CAS:
7770-78-7
Purity:
>99% (HPLC)
SDS:
 AG-CN2-0530-M050 50 mg inquire  
(-)-ARCTIIN
Alternative Names:
Arctigenin-4-glucoside; NSC 315527
CAS:
20362-31-6
Purity:
>99% (HPLC)
SDS:
 AG-CN2-0532-M010 10 mg inquire  
(-)-ARCTIIN
Alternative Names:
Arctigenin-4-glucoside; NSC 315527
CAS:
20362-31-6
Purity:
>99% (HPLC)
SDS:
 AG-CN2-0532-M050 50 mg inquire  
(-)-AS 115
CAS:
926657-43-4
Purity:
≥98%
SDS:
 CAY-13250-1 1 mg inquire  
(-)-AS 115
CAS:
926657-43-4
Purity:
≥98%
SDS:
 CAY-13250-100 100 µg inquire  
(-)-AS 115
CAS:
926657-43-4
Purity:
≥98%
SDS:
 CAY-13250-500 500 µg inquire  
(-)-BICUCULLINE METHIODIDE
Alternative Names:
N-Methylbicuculline iodide; 55950-07-7
CAS:
40709-69-1
Purity:
>95% (NMR)
 CDX-B0240-M025 25 mg inquire  
(-)-BICUCULLINE METHIODIDE
Alternative Names:
N-Methylbicuculline iodide; 55950-07-7
CAS:
40709-69-1
Purity:
>95% (NMR)
 CDX-B0240-M100 100 mg inquire  
(−)-BICUCULLINE METHOCHLORIDE
CAS:
53552-05-9
Purity:
≥98%
SDS:
 CAY-27802-10 10 mg inquire  
(−)-BICUCULLINE METHOCHLORIDE
CAS:
53552-05-9
Purity:
≥98%
SDS:
 CAY-27802-25 25 mg inquire  
(−)-BICUCULLINE METHOCHLORIDE
CAS:
53552-05-9
Purity:
≥98%
SDS:
 CAY-27802-5 5 mg inquire  
(−)-BICUCULLINE METHOCHLORIDE
CAS:
53552-05-9
Purity:
≥98%
SDS:
 CAY-27802-50 50 mg inquire  
(–)-BLEBBISTATIN
Alternative Names:
(S)-Blebbistatin
CAS:
856925-71-8
Purity:
≥98%
SDS:
 CAY-13013-1 1 mg inquire  
(–)-BLEBBISTATIN
Alternative Names:
(S)-Blebbistatin
CAS:
856925-71-8
Purity:
≥98%
SDS:
 CAY-13013-10 10 mg inquire  
(–)-BLEBBISTATIN
Alternative Names:
(S)-Blebbistatin
CAS:
856925-71-8
Purity:
≥98%
SDS:
 CAY-13013-25 25 mg inquire  
(–)-BLEBBISTATIN
Alternative Names:
(S)-Blebbistatin
CAS:
856925-71-8
Purity:
≥98%
SDS:
 CAY-13013-5 5 mg inquire  
(−)-BORNEOL
Alternative Names:
(1S)-(-)-Borneol|endo-(-)-Borneol|L-Borneol
CAS:
464-45-9
Purity:
≥95%
SDS:
 CAY-23468-10 10 mg inquire  
(−)-BORNEOL
Alternative Names:
(1S)-(-)-Borneol|endo-(-)-Borneol|L-Borneol
CAS:
464-45-9
Purity:
≥95%
SDS:
 CAY-23468-50 50 mg inquire  
(-)-CAMPHORIC ACID
Alternative Names:
(1S,3R)-1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acid
CAS:
560-09-8
Purity:
>98% (HPLC)
 CDX-C0144-G001 1 g inquire  
(-)-CAMPHORIC ACID
Alternative Names:
(1S,3R)-1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acid
CAS:
560-09-8
Purity:
>98% (HPLC)
 CDX-C0144-G010 10 g inquire  
(−)-CARYOPHYLLENE OXIDE
Alternative Names:
BCP oxide|β-Caryophyllene epoxide|β-Caryophyllene oxide
CAS:
1139-30-6
Purity:
≥98%
SDS:
 CAY-21573-1 1 g inquire  
(−)-CARYOPHYLLENE OXIDE
Alternative Names:
BCP oxide|β-Caryophyllene epoxide|β-Caryophyllene oxide
CAS:
1139-30-6
Purity:
≥98%
SDS:
 CAY-21573-100 100 mg inquire  
(-)-CATECHIN
Alternative Names:
(2S,3R)-Catechin; ent-Catechin; L-Catechin; NSC 81746; (-)-Catechol; (-)-trans-3,3',4',5,7-Pentahydroxyflavane; (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
CAS:
18829-70-4
Purity:
>97% (HPLC)
 CDX-C0453-M005 5 mg inquire  
(-)-CATECHIN
Alternative Names:
(2S,3R)-Catechin; ent-Catechin; L-Catechin; NSC 81746; (-)-Catechol; (-)-trans-3,3',4',5,7-Pentahydroxyflavane; (2S,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
CAS:
18829-70-4
Purity:
>97% (HPLC)
 CDX-C0453-M025 25 mg inquire  
(−)-CATECHIN
Alternative Names:
(2S,3R)-Catechin|ent-Catechin|L-Catechin|NSC 81746
CAS:
18829-70-4
Purity:
≥98%
SDS:
 CAY-18644-1 1 mg inquire  
(−)-CATECHIN
Alternative Names:
(2S,3R)-Catechin|ent-Catechin|L-Catechin|NSC 81746
CAS:
18829-70-4
Purity:
≥98%
SDS:
 CAY-18644-10 10 mg inquire  
(−)-CATECHIN
Alternative Names:
(2S,3R)-Catechin|ent-Catechin|L-Catechin|NSC 81746
CAS:
18829-70-4
Purity:
≥98%
SDS:
 CAY-18644-25 25 mg inquire  
(−)-CATECHIN
Alternative Names:
(2S,3R)-Catechin|ent-Catechin|L-Catechin|NSC 81746
CAS:
18829-70-4
Purity:
≥98%
SDS:
 CAY-18644-5 5 mg inquire  
(−)-CATECHIN GALLATE
Alternative Names:
(–)-CG
CAS:
130405-40-2
Purity:
≥98%
SDS:
 CAY-24963-1 1 mg inquire  
(−)-CATECHIN GALLATE
Alternative Names:
(–)-CG
CAS:
130405-40-2
Purity:
≥98%
SDS:
 CAY-24963-10 10 mg inquire  
(−)-CATECHIN GALLATE
Alternative Names:
(–)-CG
CAS:
130405-40-2
Purity:
≥98%
SDS:
 CAY-24963-25 25 mg inquire  
(−)-CATECHIN GALLATE
Alternative Names:
(–)-CG
CAS:
130405-40-2
Purity:
≥98%
SDS:
 CAY-24963-5 5 mg inquire  
(–)-CHAETOMININE
CAS:
918659-56-0
Purity:
≥95%
SDS:
 CAY-13135-2.5 2.5 mg inquire  
(–)-CHAETOMININE
CAS:
918659-56-0
Purity:
≥95%
SDS:
 CAY-13135-500 500 µg inquire  
(−)-COTININE
Alternative Names:
NIH 10498
CAS:
486-56-6
Purity:
≥98%
SDS:
 CAY-15314-100 100 mg inquire  
(−)-COTININE
Alternative Names:
NIH 10498
CAS:
486-56-6
Purity:
≥98%
SDS:
 CAY-15314-250 250 mg inquire  
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