Vinci-Biochem Srl
Via Ponte di Bagnolo, 10
50059 Vinci (Firenze) Italy
vb@vincibiochem.it
Tel: +39 0571 568 147 -
 0571 568 135
Fax: +39 0571 568132 - P. IVA 05706610481

 

cGAMP ELISA Kit

 

cGAMP Elisa Kit Cayman

 

 

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic acids in the cytosol of mammalian cells as an indicator of bacterial or viral infection. cGAS catalyzes the synthesis of a second messenger, 2’3’-cGAMP, from cytosolic ATP and GTP in response to dsDNA binding. 2’3’-cGAMP then binds tightly to the adaptor protein STING (stimulator of interferon genes), resulting in the recruitment of TBK1 and subsequent IRF3 phosphorylation. IRF3 induces the transcription and translation of type I interferon, a potent antiviral cytokine. Activation of cGAS and the production of 2’3’-cGAMP are important in host defense but also may play role in autoimmune or inflammatory diseases. Modulation of cGAS activity with subsequent inhibition of induction of 2’3’-cGAMP formation is an active target of pharmacological intervention.

Synonyms: 2'3'-Cyclic GMP-AMP, and Guanosine-Adenosine 2',3'-cyclic monophosphate

 

 

Product code: 501700

 

• Measure 2'3'-cGAMP in cell lysates
• Assay 24 samples in triplicate or 36 samples in duplicate
• Lower limit of detection (LLOD) is 9.6 pg/ml (0.01 pmol/ml)
• Run with overnight or 2-hour incubation protocols without compromising sensitivity

 

cGAMP ELISA 1

cGAMP ELISA 2

 

 

 

cGAMP ELISA 2

   

    

Innate Immune Signaling cGAS STING - Cayman Currents

Cayman Currents

Innate Immune Signaling: cGAS STING

   

 

 

 

 





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    Vinci-Biochem Srl
    Via Ponte di Bagnolo, 10
    50059 Vinci (Firenze) Italy
    vb@vincibiochem.it
    Tel:+39 0571 568147
    Fax:+39 0571 568132
    P. IVA 05706610481